Known Causes of Polycystic Ovary Syndrome
Research and clinical experience point to several overlapping causes that disrupt the normal hormonal cycle in women with PCOS:
- Insulin resistance: When cells do not respond properly to insulin, the pancreas produces more of it. High insulin levels signal the ovaries to produce excess androgens, which disrupts ovulation and leads to irregular periods.
- Elevated androgen levels: Higher than normal levels of male hormones like testosterone and DHEA suppress the normal release of eggs, cause acne, and lead to unwanted facial or body hair growth.
- Low-grade chronic inflammation: Women with PCOS often have elevated inflammatory markers. This inflammation stimulates the ovaries to produce androgens and worsens insulin resistance, creating a cycle that is hard to break.
- LH and FSH imbalance: In PCOS, the ratio of luteinizing hormone to follicle-stimulating hormone is often skewed. This prevents follicles from maturing fully and stops ovulation from happening each month.
- Genetic predisposition: PCOS tends to run in families. If your mother or sister has PCOS or type 2 diabetes, your own risk is significantly higher, suggesting an inherited component to how the body regulates hormones.
- Chronic stress and cortisol dysregulation: Prolonged stress raises cortisol levels, which affects adrenal androgen production and can worsen hormonal imbalance over time.