Arsenicum Album
This is one of the most commonly used remedies for asthma that worsens after midnight, typically between 1 and 3 in the morning. The patient wakes with a feeling of constriction in the chest, restlessness and anxiety, and often feels compelled to sit upright to breathe. There is usually a thin, watery, burning nasal discharge alongside the breathlessness, and symptoms are worse in cold air but the person still feels anxious and chilly. It is often indicated in people who are meticulous, fearful and easily fatigued.